You must be at least 18 years old to send in a sample. If you are younger, but want to participate, it must be with parental or guardian consent. There is no upper age limit, as long as you are healthy and do not have any restrictions or limitations that would prevent you from providing us with a sample.
The standard time for your report to be ready is within 7 weeks. As soon as processing is complete, the lab will report your data to OriginalGENE. After quality review, we will then compute your results and notify you via email. You must log in to your account on our website and view your genetic report.
You have the right to cancel your order within 7 days of the date of order. If you wish to do so after this seven-day period, OriginalGENE reserves the right not to refund any payment made by you, any less any delivery and/or consumable costs incurred.
Saliva samples offer an easy-to-use way for us to obtain sufficient amount of DNA to perform our analysis. It is painless and non-invasive compared to hair or blood samples. Moreover, cheek swabs are easily contaminated and often do not yield enough DNA needed from the lab.
We encourage you to send your sample right away, however the liquid in the funnel lid is designed to stabilize your saliva during transportation, so it would keep it safe even if you do not return it immediately.
There is a possibility that your saliva sample was contaminated or did not yield enough DNA for it to be processed. In such an event, we will notify you and a replacement test kit will be sent for the collection process to be repeated. In order to avoid this inconvenience, make sure you have read the instructions carefully.
The human organism is made of approximately 50 trillions of cells, inside which there are chromosomes. We have 23 pairs of chromosomes – one pair is from our mother and the other comes from our father. These chromosomes are constituted by deoxyribonucleic acid (DNA). A person’s DNA is the blueprint for all the information they need to develop, live and reproduce. It is made up of molecules called nucleotides. Each nucleotide contains a phosphate group, a sugar group and a nitrogen base. The four types of nitrogen bases are adenine (A), thymine (T), guanine (G) and cytosine (C). The order of these bases is what determines DNA's instructions, or genetic code. Similar to the way the order of letters in the alphabet can be used to form a word, the order of nitrogen bases in a DNA sequence forms genes, which in the language of the cell, tells cells how to make proteins needed for our bodies to grown and function properly.
Single nucleotide polymorphism (SNP, pronounced “snip”) is a site within the genome that differs by a single nucleotide base across different individuals. The cells in our body are constantly diving into two in order to make new cells. For this to happen, a cell first copies its DNA so that when it is divided, the new cell would have all the necessary genetic information. During this copying process, mistakes can happen. Those mistakes lead to variations in our DNA sequence at a specific location. And this is how a SNP is created. Those SNPs can cause differences in the instructions needed for the proteins, which in turn can influence a variety of traits. Such traits could be in physical appearance, disease susceptibility or response to drugs.
Once our CLIA-certified lab receives your sample, there is a strict procedure to be followed. First your sample is inspected to make sure there is a sufficient amount of DNA for completing the analysis. After the DNA is extracted from the cells in your saliva, it is amplified (copied) it order to ensure there is enough of it. Since quality is important to us, we use a special chip, designed by Affymetrix, for genotyping the SNPs. When the sample is successfully analyzed, the lab sends us the results, which we thoroughly review. The last step is sending an email notifying you that your genetic report is ready.
Even though both genotyping and sequencing are techniques used to obtain information about the DNA, they have a few key differences. Genotyping is the process that determines which genetic variants are possessed by a certain individual. It can be performed by different techniques depending on the variants of interest or the resources available. Sequencing is the process of determining the correct order of the nucleotide in a given fragment of DNA. You can sequence a short fragment, the whole genome or parts of the genome. The analysis performed by OriginalGENE is genotyping and not sequencing.
Your results would be accurate for the vast majority of medical conditions or if you are pregnant. The one exception when we do not recommend taking this type of genetic test is if you have received a bone marrow transplant. In this case, your white blood cells will contain the DNA of your donor. Such cells can be found in small amounts in your saliva, so when you send us your sample, this DNA will not match your own and the analysis can fail.
No. The information provided by OriginalGENE is intended for educational purposes only and is not for diagnostic use. We cannot predict your future health, nor provide professional medical or clinical services or advice. Our reports do not contain medical advice and you should not change your health behaviors solely on the basis of information from OriginalGENE. If you think you have a medical emergency or need such an advice, we encourage you to contact a physician.
The results of genetic tests are not simply “yes or no” for the risk of developing disease. Mainly, diseases occur as a result of interaction among multiple genes and the environmental factors — a person’s way of living, the foods they eat, and the substances to which they are exposed, such as sunlight, chemicals or tobacco. Those interactions in contributing to health and disease can be very complex. A positive result means that the testing laboratory found unusual characteristics or changes in the genes it tested. Such result may identify an increased risk of developing a disease, or indicate that a person is a carrier for a particular disease. It does not necessarily mean that a disease will develop, or if it does, that the disease will be progressive or severe. A negative result means that the laboratory found no unusual characteristics or changes in the genes it tested. This could mean that a person does not have an increased risk of developing the disease, is not a carrier of the disease or it could mean that the test did not examine or has missed the specific genetic changes associated with a particular disease. This is why OriginalGENE do not offer any medical advice and it is important not to make any life changing decisions based solely on this report.
We at OriginalGENE believe that knowledge is power and aim to help you get access to your genetic information, understand it and benefit from it. An insight into your genetic predispositions can help you tailor your exercise and nutrition plans to the best way possible. With just a simple saliva sample, you will get access to your genetic information quickly and be able to better adjust your environment for optimal health and fitness. Moreover, you would obtain interesting information about yourself, what makes you unique and what you share with the important people in your life.
The science behind the significance or interpretation of certain testing results continues to evolve. Although great strides have been made to advance the potential usefulness of genetic testing, there is still much to be discovered. Genetic testing is based upon information, developments and testing techniques that are known today. Future research may reveal changes in the interpretation of previously obtained genetic testing results. For example, any genetic test is limited by the variants being tested. The interpretation of the significance of some variants may change as more research is done about them. Some variants that are associated with disease, drug response, or diet, nutrition and exercise response may not be tested; possibly these variants have not yet been identified in genetic studies. Many of the conditions and drug responses that are tested are dependent on genetic factors as well as nongenetic factors such as age, personal and family health history, diet, and ethnicity. As such, an individual may not exhibit the specific drug response, disease, diet, nutrition and exercise response consistent with the genetic test results.
OriginalGENE is not a diagnostic test and cannot predict your future health. We do not provide professional medical or clinical services or advice. The services provided by the websites do not contain, and should not be interpreted as, medical or clinical advice or opinion. No doctor-patient relationship is created. Use of the services is not for medical diagnostics or emergencies. If you think you have a medical emergency, you should contact a physician.
OriginalGENE is owned and operated by ORG SERVICES LIMITED, 1st floor Romer House, 132 Lewisham High Street, London, SE13 6EE, United Kingdom.